Principal Scientist

Company: Initial Therapeutics, Inc.
Location: Thousand Oaks
Posted on: May 24, 2025

Job Description:

Join Amgen's Mission of Serving PatientsAt Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission to serve patients living with serious illnesses drives all that we do.Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas: Oncology, Inflammation, General Medicine, and Rare Disease, we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives.Our award-winning culture is collaborative, innovative, and science-based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.Principal ScientistWhat you will doLet's do this. Let's change the world. We are seeking a highly motivated Principal Scientist to join the Structural Biology group at our site in Thousand Oaks, CA. The Structural Biology group provides comprehensive molecular insights and structure-based design for drug-target assessment, mechanism of action, protein-protein and protein-ligand interactions, as well as protein engineering to facilitate drug discovery across various therapeutic areas. The Principal Scientist will be responsible for structure determination of target molecules using X-ray crystallography and cryo-electron microscopy (cryo-EM).

• Interact directly with small molecule scientists including computational scientists, medicinal chemists, and protein engineers.
• Apply knowledge to new areas of study, with strong interpersonal and communication skills to thrive in a highly collaborative environment.What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications.Basic Qualifications:
  • Ph.D. with a deep understanding of structural biology and general biochemistry and biophysics.
  • Significant postdoctoral AND industrial (pharma/biotech) research experience, in large macromolecular complex structure determination. Knowledge of state-of-the-art protein structural biology techniques including all aspects of construct design, expression, purification, characterization, structure determination, and analysis.
  • Proven expertise on protein crystallography AND cryo-EM single particle analysis, to determine atomic resolution structures.
  • Experience with ubiquitin-proteasome system for protein degradation is a plus.
  • Excellent presentation skills (written and oral) for effective team-based communication of results.
  • Ability to work independently and effectively within timelines and to collaborate in a multidisciplinary environment.
  • Willingness to take on new/unfamiliar responsibilities to help the team.
  • Skills in managing multiple projects and capability to prioritize.Preferred Qualifications:
    • Experience with other protein biochemical and/or biophysical characterization of protein complexes.What you can expect of usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
      • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
      • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
      • Stock-based long-term incentives.
      • Award-winning time-off plans.
      • Flexible work models, including remote and hybrid work arrangements, where possible.Apply nowfor a career that defies imagination.Objects in your future are closer than they appear. Join us.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
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Keywords: Initial Therapeutics, Inc., Lompoc , Principal Scientist, Education / Teaching , Thousand Oaks, California